مقدمه نویسنده
ساخت مواد مخدر ان چنان هم که به نظر می اید ساده و آسان نیست
ترجمه متون شیمیایی ساخت مواد مخدر بسیار مشکل است و اگر شخص پایه اولیه برای شناخت مواد شیمیایی را نداشته باشد تقریبا فهم مسله غیر ممکن است
ماده مخدر لبخند این روزها در غرب جزو مواد مخدر رایجی است که سرو صدای زیادی به پا کرده است
این ترجمه ساخت ماده مخدر لبخند توسط سایت Das Online-Magazin für Psychonauten Psychotropiconاست که البته مطمعن هستم کسی از ان سر در نمی اورد ولی برای شروع کار ترجمه متون ساخت مواد مخدر گذاشته ام ؟؟
البته به مرور و وقتی بیکار هستم سعی می کنیم انرا به زبان فارسی روان ترجمه کنم
2،5-DIMETHOXY-4-IODOPHENETHYLAMINE
ساخت مواد مخدر ان چنان هم که به نظر می اید ساده و آسان نیست
ترجمه متون شیمیایی ساخت مواد مخدر بسیار مشکل است و اگر شخص پایه اولیه برای شناخت مواد شیمیایی را نداشته باشد تقریبا فهم مسله غیر ممکن است
ماده مخدر لبخند این روزها در غرب جزو مواد مخدر رایجی است که سرو صدای زیادی به پا کرده است
این ترجمه ساخت ماده مخدر لبخند توسط سایت Das Online-Magazin für Psychonauten Psychotropiconاست که البته مطمعن هستم کسی از ان سر در نمی اورد ولی برای شروع کار ترجمه متون ساخت مواد مخدر گذاشته ام ؟؟
البته به مرور و وقتی بیکار هستم سعی می کنیم انرا به زبان فارسی روان ترجمه کنم
2،5-DIMETHOXY-4-IODOPHENETHYLAMINE
ساخت ماده مخدر 2C-I
سنتز:ترکیبی از 7.4 گرم انیدرید phthalic و 9.05 گرم 2،5-dimethoxyphenethylamine (نگاه کنید، این دستور را برای آماده سازی 2C-Hهم بکار می رود) با شعله باز گرم می کنیم . تک فاز روشن با از دست دادن H2O تشکیل شد. پس از ذوب گرم آرام برای چند لحظه باقی ماند، آن را به یک ظرف متبلور بازده 14.8 گرم از محصول جامد خام ریخته می شد. این از 20 میلی لیتر CH3CN با دقت گرفته شده برای انحلال گرماگیر و گرمازا تبلور recrystallized شد. هر دو انتقال باید بدون عجله انجام می شود. پس از تصفیه، مواد جامد با 2 شستشو داده شدند × 20 میلی لیتر هگزان و هوا به وزن ثابت خشک است. عملکرد 12.93 گرم N (2 - (2،5-dimethoxyphenyl) اتیل) phthalimide شد و به عنوان کریستالهای زرد رنگ الکترواستاتیک، به دست آمده با MP 109-111 درجه سانتی گراد نمونه از IPA recrystallized شد سفید، با یک نماینده 110-111 درجه سانتی گراد مقعد. (C18H17NO4) C، H، N.
به یک راه حل در 130 میلی لیتر از 12.9 گرم N-(2 - (2،5-dimethoxyphenyl) اتیل) phthalimide گرم (35 ° C) اسید استیک که به شدت هم زده، یک راه حل از 10 گرم monochloride ید اضافه شده بود در 40 میلی لیتر اسید استیک. این برای 1 ساعت هم زده شد، در حالی که در حدود 30 درجه سانتی گراد برگزار شد مخلوط واکنش را به 1500 میلی لیتر H2O ریخته شد و استخراج و با 4 × 75 میلی لیتر CH2Cl2. عصاره، مخلوط شده و یک بار با 150 میلی لیتر H2O حاوی 2.0 dithionite سدیم گرم شسته و تحت خلاء حذف حلال را به 16.2 گرم N-(2 - (2،5-dimethoxy-4-iodophenyl) اتیل) phthalimide به عنوان رنگ زرد کهربایی مواد جامد با MP 133-141 درجه سانتی گراد این نماینده توسط تبلور مجدد از 75 میلی لیتر CH3CN بهبود یافته، بازده 12.2 گرم از ماده جامد و به رنگ زرد کمرنگ با MP 149-151 درجه سانتی گراد نمونه کوچکی از یک مقدار زیادی از IPA می دهد ذوب محصول سفید در 155.5-157 درجه سانتی گراد
به یک راه حل در 130 میلی لیتر از 12.9 گرم N-(2 - (2،5-dimethoxyphenyl) اتیل) phthalimide گرم (35 ° C) اسید استیک که به شدت هم زده، یک راه حل از 10 گرم monochloride ید اضافه شده بود در 40 میلی لیتر اسید استیک. این برای 1 ساعت هم زده شد، در حالی که در حدود 30 درجه سانتی گراد برگزار شد مخلوط واکنش را به 1500 میلی لیتر H2O ریخته شد و استخراج و با 4 × 75 میلی لیتر CH2Cl2. عصاره، مخلوط شده و یک بار با 150 میلی لیتر H2O حاوی 2.0 dithionite سدیم گرم شسته و تحت خلاء حذف حلال را به 16.2 گرم N-(2 - (2،5-dimethoxy-4-iodophenyl) اتیل) phthalimide به عنوان رنگ زرد کهربایی مواد جامد با MP 133-141 درجه سانتی گراد این نماینده توسط تبلور مجدد از 75 میلی لیتر CH3CN بهبود یافته، بازده 12.2 گرم از ماده جامد و به رنگ زرد کمرنگ با MP 149-151 درجه سانتی گراد نمونه کوچکی از یک مقدار زیادی از IPA می دهد ذوب محصول سفید در 155.5-157 درجه سانتی گراد
راه حل از 12.2 گرم N-(2 - (2،5-dimethoxy-4-iodophenyl) اتیل) phthalimide در 150 میلی لیتر IPA گرم با 6.0 میلی لیتر هیدرات هیدرازین تحت درمان قرار گرفت، و راه حل روشن بر روی حمام بخار حرارت داده شد. بعد از چند دقیقه نسل یک کلبه سفید پنیر مانند جامد (1،4-dihydroxyphthalizine) وجود دارد. حرارت دادن را برای چند ساعت اضافی در ادامه، مخلوط واکنش سرد و جامد توسط فیلتراسیون حذف شده است. این را با 2 × 10 میلی لیتر ETOH، و محلول صاف شده مخلوط شستشو داده شدند و شستشو حلال تحت خلا دادن باقی مانده است که، زمانی که با اسید هیدروکلریک آبی درمان به 3.43 گرم از بلورهای بزرگ سفید قالب بندی نشده این مطلب هستید. این، پس از تبلور مجدد از 2 وزن H2O، فیلتر کردن، برای اولین بار با IPA و سپس با Et2O شستشو و خشک کردن هوا، به 2.16 گرم 2،5-dimethoxy-4-iodophenethylamine هیدروکلراید (2C-I) را به عنوان یک جامد microcrystalline سفید، با نماینده 246-247 درجه سانتی گراد مقعد. شود (C10H15ClINO2) C، H، N.
مقدار مصرف:14 - 22 میلی گرم است.
مدت زمان:6 تا 10 ساعت.
نظر کیفی (با 0 میلی گرم) در حال حاضر در نشست گروه بود، اما تنها یک ناظر. با صفر میلی گرم 2C-، قادر به رسیدن به لذت و به علاوه 2.5 در حدود پنج دقیقه پس از من در محل خود را وارد و جذب محیط از مردمی که در واقع imbibed مواد. سطح من حدود چهار ساعت به طول انجامید و در حدود همان زمان بود به عنوان دیگران. هیچ عوارض پس از تجربه به جز یک خستگی خوشایند وجود دارد.
(با 15 میلی گرم) شروع راحت است. قابل توجه ترین، تصاویری، الگودهی مانند 2C-B (فارسی نوع فرش)، بسیار رنگارنگ و فعال هستند. تر از شخصیت عاطفی متعادل، اما هنوز هم هیچ احساس از بینش، وحی، یا پیشرفت به سوی معنای واقعی جهان است. و در 5/2 1 ساعت افت کردن ناگهانی، پس از آن کاهش ملایم. من می خواهم به بررسی سطوح موزه.
(با 16 میلی گرم)، یک هشدار فوری در عرض چند دقیقه وجود دارد. به طور معمول، تنها آگاهی، پس از آن هیچ چیزی اتفاق افتاده است در حالی که برای. در نگاهی به گذشته، برخی از انواع فعالیت یا آگاهی در عرض 40 دقیقه، که پس از آن می سازد تا در طول زمان است. در 2 ساعت به قله بود و به نظر می رسید خود را در حالی که برای حفظ کند. نزدیک قله بود، برخی از فعالیت های توهم زا وجود دارد، هر چند نه زیادی. تصاویر در اتاق غذاخوری به حال رنگ و الگوی جنبش های که نسبتا به تفصیل شد. تمرکز بر روی مناطق دیگر، مانند دیوار و یا در خارج از خانه، به تولید فعالیت های کوچک، هر چند من سعی کردم. بود قطعا وجود دارد تعداد زیادی از افزایش رنگ. نیز وجود دارد که از جنبه های عجیب و غریب از میدان دید داشتن مناطق تاریک یا سایه. این مناطق تیره تر به نظر می رسید برای تغییر تا حدی. به نظر می رسد که جنبه شبیه به 2C-B است. من فکر نمی کنم بیشتر از 2.5 در اوج بود. پایین آمدن حادثه بود. من در عرض 6 ساعت بود. من هیچ مشکلی رانندگی در خانه، و نه وجود دارد هر گونه اشکال در خواب. مشکلات بدن با این مواد وجود دارد. من مثل یک اسب خورده است.
(با 16 میلی گرم) 16 یک بیت بسیار بود، من متوجه شدم، چرا که بدن من بود از آنچه با تمام انرژی مطمئن نیست. دفعه بعد هم که من 14 یا 15 را امتحان کنید. با این حال، گفتگوهای من بسیار روشن و روشنگری است. درجه از صداقت باور نکردنی بود. ترسیده بودم می گویند هر چیزی به هر کسی نیست. احساس خوبی در مورد خودم. خیلی خیلی خیلی، در واقع محور. کمی در پایان روز خسته می شوند. زمان خواب در اوایل.
(با 20 میلی گرم) من فکر می کنم کمی کمتر از غوطه وری کامل در نفسانی، با این مواد، در مقایسه با 2C-B، اما من گمان آن است بیشتر مسئله شدن به زبان 2C-I استفاده می شود و احساسات و گرفتن تنظیم فرکانس کمی متفاوت، در واقع به جای که مواد نفسانی کمتر است یا کمتر، آسان برای استفاده از sensually. فقط فرکانس های مختلف، و ما بسیار، بسیار به 2C-B استفاده می شود. خوب بر روی بدن. گذار، برای من، نه به شدت به عنوان 2C-B تاریک. اما قطعا می تواند بسیاری کاوش، اگر ما قادر به زمان (در حدود 9 ساعت) به آن بودند. روز بعد: عالی خواب. روز بعد انرژی غیر منتظره ای خوب است. کاملا شب خسته می شوند.
توسعه و تفسیر:مقایسه های مکرر بین مخدر 2C-I و 2C-B ، بدون شک، از یک بیت از پیشنهاد شیمیایی. دو ترکیبات دارای ساختار است که واقعا مشابه هستند، از لحاظ فنی است. در یک اتم ید استراتژیک واقع شده است وجود دارد، و در سوی دیگر، اتم یکسان قرار داده شده برم. اینها به طور مستقیم در بالا و زیر یک دیگر است که در جدول تناوبی است. و چه دیوانه کننده به diddler مصنوعی است، این است که می توان آنها طولانی، و یا کوتاه، یا به هیچ وجه squooshed. شما می توانید یک نسخه طولانی تر و باریک تر از یک اتم برم را ندارد، شما می توانید با، مثلا، یک گروه بوتیل انجام دهد. تو آنچه که تو کردم، مثل آن باشد یا نباشد. هیچ ظریف تغییرات وجود ندارد.
اما، در سمت روشن تر از تصویر شما باید یک اتم سنگین، و این اتم به فعالیت مرکزی از ترکیب ذاتی است. بنابراین، این مواد طبیعی برای برچسب آزمایشات رادیویی هستند. 2C من شده است با رادیو، ید رادیو اکتیو ساخته شده، اما چشمگیر ترین یافته ها با آنالوگ 3 کربن، DOI ساخته شده اند.
یک نقل قول از یک ناظر از آزمایش به یک گروه محصور در خشکی است، یک آزمایش با صفر میلی گرم گرفته است. مشاهده آموزنده از آنچه بوده است به نام یک مخاطب بالا است.
1 Iodotweetio شناخته شده وجود دارد. در دستمالی کردن، کلمه ای که تا به حال هفت نفر از آن یازده نامه به عنوان واکه ها را به چالش می کشند؟ به خصوص اگر صدادار بود، به طور خاص، iooeeio؟ فقط یک کمی مانند سر و صدای بیرون آمدن از مزرعه مک دونالد به آن را برای تلفن های موبایل. اما Tweetio است وجود دارد، یعنی، 2-ETO-homologue 2C-. این 2-ethoxy 4 iodo-5-methoxyphenethylamine، یا 2CI-2ETO است. نمک هیدروکلراید، محصول سفید و بلورین که با نقطه ذوب 175-175.5 درجه سانتی گراد بود سطح آستانه فعالیت در یک دوز خوراکی از 5 میلی گرم دیده می شود و اثرات تولید شده به طور کامل در چند ساعت متفرق شدند. جالب توجه است، بزرگتر دوز، حداکثر به 50 میلی گرم به صورت خوراکی، به نظر می رسد برای تولید بیشتر شدید اثر است، اما به سادگی به این آستانه را برای چند ساعت اضافی را دراز. در سطح است که سعی شده است، 2CI-2EtO تولید حتی یک پاسخ به همراه دو.
کجا دیگر می تواند یک بروید، از 2C-؟ ید چهارم و آخر به اصطلاح هالوژنها است، در پایین جدول تناوبی کلاسیک. اما، به لطف معجزه است که ما را به عصر هسته ای همراه است، یک پنجم هالید در حال حاضر شناخته می شود، استتین، وجود دارد. تمام ایزوتوپ های آن رادیواکتیو هستند، با این حال، به نظر می رسد و بعید است که تا کنون وجود خواهد داشت که ورود (به غیر از این یکی) 2،5-dimethoxy-4-astatophenethylamine. چه ممکن است به فعالیت های خود را این باورند؟ احتمالا مشابه در قدرت به 2C-I، نیاز شاید 10 یا 20 میلی گرم است. طول مدت خواهد بود dicey برای اندازه گیری، از ایزوتوپ با طولانی ترین نیمه عمر شناخته شده است 1/2 فاسد در حدود 8 ساعت، طولانی ترین عمر ایزوتوپی طبیعی (برای کسانی که در طبیعی به جای اصرار چیزهایی از انسان ساخته) نصف فاسد در کمتر از یک دقیقه. دو پیش بینی خواهد بود خیلی جامد است. شما ممکن است کاملا یک کار انباشته خود را 10 میلی گرم از استاتین، به عنوان است که تا کنون در یک زمان ساخته شده است تنها در حدود 0.05 میکروگرم در حدود یک میلیونیوم از مقدار مورد نیاز است. و دوم پیش بینی؟ شما می توانید تابش جیغ که شما اگر شما می توانید 5 یا 10 نیاز میلی گرم از رادیو-استاتین بر روی آن سحر و جادو 4-موقعیت بمباران زنده ماندن نیست، و در نتیجه 2C-A را به معده شما را
#33 2C-I
2,5-DIMETHOXY-4-IODOPHENETHYLAMINE
SYNTHESIS: A mixture of 7.4 g phthalic anhydride and 9.05 g of
2,5-dimethoxyphenethylamine (see the recipe for 2C-H for its
preparation) was heated with an open flame. A single clear phase was
formed with the loss of H2O. After the hot melt remained quiet for a
few moments, it was poured out into a crystallizing dish yielding 14.8
g of a crude solid product. This was recrystallized from 20 mL CH3CN,
with care taken for an endothermic dissolution, and an exothermic
crystallization. Both transitions must be done without haste. After
filtration, the solids were washed with 2x20 mL hexane and air dried
to constant weight. A yield of 12.93 g of
N-(2-(2,5-dimethoxyphenyl)ethyl)phthalimide was obtained as
electrostatic yellow crystals, with a mp of 109-111 °C. A sample
recrystallized from IPA was white, with a mp of 110-111 °C. Anal.
(C18H17NO4) C,H,N.
To a solution of 12.9 g N-(2-(2,5-dimethoxyphenyl)ethyl)phthalimide in 130 mL warm (35 °C) acetic acid which was being vigorously stirred, there was added a solution of 10 g iodine monochloride in 40 mL acetic acid. This was stirred for 1 h, while being held at about 30 °C. The reaction mixture was poured into 1500 mL H2O and extracted with 4x75 mL CH2Cl2. The extracts were pooled, washed once with 150 mL H2O containing 2.0 g sodium dithionite, and the solvent removed under vacuum to give 16.2 g of N-(2-(2,5-dimethoxy-4-iodophenyl)ethyl)phthalimide as yellow amber solids with a mp of 133-141 °C. This mp was improved by recrystallization from 75 mL CH3CN, yielding 12.2 g of a pale yellow solid with mp 149-151 °C. A small sample from a large quantity of IPA gives a white product melting at 155.5-157 °C.
A solution of 12.2 g N-(2-(2,5-dimethoxy-4-iodophenyl)ethyl)phthalimide in 150 mL hot IPA was treated with 6.0 mL of hydrazine hydrate, and the clear solution was heated on the steam bath. After a few minutes there was the generation of a white cottage cheese-like solid (1,4-dihydroxyphthalizine). The heating was continued for several additional h, the reaction mixture cooled, and the solids removed by filtration. These were washed with 2x10 mL EtOH, and the pooled filtrate and washes stripped of solvent under vacuum giving a residue which, when treated with aqueous hydrochloric acid, gave 3.43 g of voluminous white crystals. This, after recrystallization from 2 weights of H2O, filtering, washing first with IPA and then with Et2O, and air drying, gave 2.16 g 2,5-dimethoxy-4-iodophenethylamine hydrochloride (2C-I) as a white microcrystalline solid, with a mp of 246-247 °C. Anal. (C10H15ClINO2) C,H,N.
DOSAGE: 14 - 22 mg.
DURATION: 6 - 10 h.
QUALITATIVE COMMENTS (with 0 mg) I was present at a group meeting, but was only an observer. With zero milligrams of 2C-I, I was able to get to a delightful plus 2.5 in about five minutes after I arrived at your place, and absorbed the ambience of the folks who had actually imbibed the material. My level lasted about four hours and came down at about the same time as did the others. There were no after-effects experienced except for a pleasant languor.
[Erowid Note: We received several requests for clarification of this note. Alexander Shulgin confirmed that this experience was a contact-high from being near a group of people on 2C-I. He writes:
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[3D .jpg image] [3D .mol structure] |
To a solution of 12.9 g N-(2-(2,5-dimethoxyphenyl)ethyl)phthalimide in 130 mL warm (35 °C) acetic acid which was being vigorously stirred, there was added a solution of 10 g iodine monochloride in 40 mL acetic acid. This was stirred for 1 h, while being held at about 30 °C. The reaction mixture was poured into 1500 mL H2O and extracted with 4x75 mL CH2Cl2. The extracts were pooled, washed once with 150 mL H2O containing 2.0 g sodium dithionite, and the solvent removed under vacuum to give 16.2 g of N-(2-(2,5-dimethoxy-4-iodophenyl)ethyl)phthalimide as yellow amber solids with a mp of 133-141 °C. This mp was improved by recrystallization from 75 mL CH3CN, yielding 12.2 g of a pale yellow solid with mp 149-151 °C. A small sample from a large quantity of IPA gives a white product melting at 155.5-157 °C.
A solution of 12.2 g N-(2-(2,5-dimethoxy-4-iodophenyl)ethyl)phthalimide in 150 mL hot IPA was treated with 6.0 mL of hydrazine hydrate, and the clear solution was heated on the steam bath. After a few minutes there was the generation of a white cottage cheese-like solid (1,4-dihydroxyphthalizine). The heating was continued for several additional h, the reaction mixture cooled, and the solids removed by filtration. These were washed with 2x10 mL EtOH, and the pooled filtrate and washes stripped of solvent under vacuum giving a residue which, when treated with aqueous hydrochloric acid, gave 3.43 g of voluminous white crystals. This, after recrystallization from 2 weights of H2O, filtering, washing first with IPA and then with Et2O, and air drying, gave 2.16 g 2,5-dimethoxy-4-iodophenethylamine hydrochloride (2C-I) as a white microcrystalline solid, with a mp of 246-247 °C. Anal. (C10H15ClINO2) C,H,N.
DOSAGE: 14 - 22 mg.
DURATION: 6 - 10 h.
QUALITATIVE COMMENTS (with 0 mg) I was present at a group meeting, but was only an observer. With zero milligrams of 2C-I, I was able to get to a delightful plus 2.5 in about five minutes after I arrived at your place, and absorbed the ambience of the folks who had actually imbibed the material. My level lasted about four hours and came down at about the same time as did the others. There were no after-effects experienced except for a pleasant languor.
[Erowid Note: We received several requests for clarification of this note. Alexander Shulgin confirmed that this experience was a contact-high from being near a group of people on 2C-I. He writes:
I realize that some readers think that Ann and I are the authors of all the commentaries but in reality they have come from many different authors.
I have dug around in my notes and have finally found the origin of the zero milligram comment. It was a group experiment with 2C-I. Two members of the group arrived after everyone else had started and decided not to make a late entry, simply enjoy being observers. They reported that one of them turned on almost immediately, and went up to a plus two and a half. Further into his research notes he wrote that he had "absorbed the ambience of the folks who had actually imbibed the material," and this was transferred directly to Pihkal. I hoped that this would make it obvious that it was a contact high, not a drug-induced high. -- Alexander Shulgin, Oct 2004 personal communication.
We hope that clarifies the issue.]
(with 15 mg) Comfortable onset. Most notable are the visuals, patterning like 2C-B (Persian carpet type), very colorful and active. Much more balanced emotional character, but still no feeling of insight, revelation, or progress toward the true meaning of the universe. And at 5 1/2 hours drop-off very abrupt, then gentle decline. I would like to investigate museum levels.
(with 16 mg) There was an immediate alert within minutes. As usual, it was only an awareness, then nothing happened for a while. In retrospect, I see some type of activity or awareness within 40 minutes, which then builds up over time. The peak was at 2 hours and seemed to maintain itself for a while. Near the peak, there was some hallucinogenic activity, though not a lot. The pictures in the dining room had color and pattern movement that was fairly detailed. Focusing on other areas, such as walls or the outside of the house, produced little activity, though I tried. There was certainly a lot of color enhancement. There was also that peculiar aspect of the visual field having darkened or shadowed areas. These darker areas seemed to shift around to some degree. That aspect seems to be similar to 2C-B. I don't think I was more than +2.5 at the peak. Coming down was uneventful. I was down within 6 hours. I had no problems driving home, nor were there any difficulties with sleep. There were no body problems with this material. I ate like a horse.
(with 16 mg) The 16 was a bit much, I realized, because my body was not sure of what to do with all the energy. Next time I'll try 14 or 15. However, my conversations were extremely clear and insightful. The degree of honesty was incredible. I was not afraid to say anything to anyone. Felt really good about myself. Very centered, in fact. A bit tired at day's end. Early bedtime.
(with 20 mg) I think there is slightly less than full immersion in the sensual, with this material, compared with 2C-B, but I suspect it's more a matter of getting used to the language of 2C-I and the feelings--getting tuned to a slightly different frequency, really-- rather than that the material is less sensual or less easy to use sensually. Just different frequency, and we are very, very used to 2C-B. Good on the body. Transition, for me, not as strongly dark as 2C-B. But it could certainly take a lot more exploring, if we were able to give the time (about 9 hours) to it. Next day: sleep excellent. Energy next day unusually good. Quite tired by evening.
EXTENSIONS AND COMMENTARY: The frequent comparisons between 2C-I and 2C-B stem, without doubt, from a bit of chemical suggestion. The two compounds have structures that are truly analogous, in technical terms. In one, there is a strategically located iodine atom, and in the other, an identically placed bromine atom. These are directly above and below one-another in the periodic table. And what is particularly maddening to the synthetic diddler, is that they cannot be lengthened, or shortened, or squooshed around in any way. You can't make a longer and narrower version of a bromine atom, as you can do with, say, a butyl group. You've got what you've got, like it or not. No subtle variations.
But, on the brighter side of the picture, you have a heavy atom here, and this atom is intrinsic to the central activity of the compound. So, these materials are naturals for radio-labelling experiments. 2C-I has been made radioactive with radio-iodine, but the most impressive findings have been made with the 3-carbon analog, DOI.
One quotation from an observer of a group experiment is enclosed; an experiment with zero milligrams being taken. This is a instructive observation of what has been called a contact high.
There is one Iodotweetio known. In Scrabble, would you challenge a word that had seven of its eleven letters as vowels? Especially if the vowels were, specifically, iooeeio? It sounds just a little like the noise coming out of Old McDonald's farm. But a Tweetio there is, namely, the 2-EtO-homologue of 2C-I. This is 2-ethoxy-4-iodo-5-methoxyphenethylamine, or 2CI-2ETO. The hydrochloride salt was a white, crystalline product with a melting point of 175-175.5 °C. The threshold level of activity was seen at an oral dose of 5 milligrams, and the generated effects were completely dispersed in a couple of hours. Most interestingly, larger doses, of up to 50 milligrams orally, seem to produce no more intense an effect, but simply to stretch out this threshold for an additional couple of hours. At no level that has been tried, has 2CI-2EtO produced even a plus-two response.
Where else can one go, from 2C-I? The iodine is the fourth, and the last of the so-called halogens, at the bottom of the classical periodic table. But, thanks to the miracles that have accompanied us into the nuclear age, there is a fifth halide now known, Astatine. All of its isotopes are radioactive, however, and it seems unlikely that there will ever be an entry (other than this one) for 2,5-dimethoxy-4-astatophenethylamine. What might be speculated as to its activity? Probably similar in potency to 2C-I, requiring maybe 10 or 20 milligrams. The duration would be dicey to measure, since the isotope with the longest known half-life is half decayed in about 8 hours, and the longest lived natural isotope (for those who insist on natural rather than man-made things) is half decayed in less than a minute. Two predictions would be pretty solid. You might have quite a job accumulating your 10 milligrams of Astatine, as the most that has so far been made at one time is only about 0.05 micrograms, approximately a millionth of the amount needed. And the second prediction? You would not survive the screaming radiation that would bombard you if you could get the needed 5 or 10 milligrams of radio-astatine onto that magic 4-position, and the resulting 2C-A into your tummy!
(with 15 mg) Comfortable onset. Most notable are the visuals, patterning like 2C-B (Persian carpet type), very colorful and active. Much more balanced emotional character, but still no feeling of insight, revelation, or progress toward the true meaning of the universe. And at 5 1/2 hours drop-off very abrupt, then gentle decline. I would like to investigate museum levels.
(with 16 mg) There was an immediate alert within minutes. As usual, it was only an awareness, then nothing happened for a while. In retrospect, I see some type of activity or awareness within 40 minutes, which then builds up over time. The peak was at 2 hours and seemed to maintain itself for a while. Near the peak, there was some hallucinogenic activity, though not a lot. The pictures in the dining room had color and pattern movement that was fairly detailed. Focusing on other areas, such as walls or the outside of the house, produced little activity, though I tried. There was certainly a lot of color enhancement. There was also that peculiar aspect of the visual field having darkened or shadowed areas. These darker areas seemed to shift around to some degree. That aspect seems to be similar to 2C-B. I don't think I was more than +2.5 at the peak. Coming down was uneventful. I was down within 6 hours. I had no problems driving home, nor were there any difficulties with sleep. There were no body problems with this material. I ate like a horse.
(with 16 mg) The 16 was a bit much, I realized, because my body was not sure of what to do with all the energy. Next time I'll try 14 or 15. However, my conversations were extremely clear and insightful. The degree of honesty was incredible. I was not afraid to say anything to anyone. Felt really good about myself. Very centered, in fact. A bit tired at day's end. Early bedtime.
(with 20 mg) I think there is slightly less than full immersion in the sensual, with this material, compared with 2C-B, but I suspect it's more a matter of getting used to the language of 2C-I and the feelings--getting tuned to a slightly different frequency, really-- rather than that the material is less sensual or less easy to use sensually. Just different frequency, and we are very, very used to 2C-B. Good on the body. Transition, for me, not as strongly dark as 2C-B. But it could certainly take a lot more exploring, if we were able to give the time (about 9 hours) to it. Next day: sleep excellent. Energy next day unusually good. Quite tired by evening.
EXTENSIONS AND COMMENTARY: The frequent comparisons between 2C-I and 2C-B stem, without doubt, from a bit of chemical suggestion. The two compounds have structures that are truly analogous, in technical terms. In one, there is a strategically located iodine atom, and in the other, an identically placed bromine atom. These are directly above and below one-another in the periodic table. And what is particularly maddening to the synthetic diddler, is that they cannot be lengthened, or shortened, or squooshed around in any way. You can't make a longer and narrower version of a bromine atom, as you can do with, say, a butyl group. You've got what you've got, like it or not. No subtle variations.
But, on the brighter side of the picture, you have a heavy atom here, and this atom is intrinsic to the central activity of the compound. So, these materials are naturals for radio-labelling experiments. 2C-I has been made radioactive with radio-iodine, but the most impressive findings have been made with the 3-carbon analog, DOI.
One quotation from an observer of a group experiment is enclosed; an experiment with zero milligrams being taken. This is a instructive observation of what has been called a contact high.
There is one Iodotweetio known. In Scrabble, would you challenge a word that had seven of its eleven letters as vowels? Especially if the vowels were, specifically, iooeeio? It sounds just a little like the noise coming out of Old McDonald's farm. But a Tweetio there is, namely, the 2-EtO-homologue of 2C-I. This is 2-ethoxy-4-iodo-5-methoxyphenethylamine, or 2CI-2ETO. The hydrochloride salt was a white, crystalline product with a melting point of 175-175.5 °C. The threshold level of activity was seen at an oral dose of 5 milligrams, and the generated effects were completely dispersed in a couple of hours. Most interestingly, larger doses, of up to 50 milligrams orally, seem to produce no more intense an effect, but simply to stretch out this threshold for an additional couple of hours. At no level that has been tried, has 2CI-2EtO produced even a plus-two response.
Where else can one go, from 2C-I? The iodine is the fourth, and the last of the so-called halogens, at the bottom of the classical periodic table. But, thanks to the miracles that have accompanied us into the nuclear age, there is a fifth halide now known, Astatine. All of its isotopes are radioactive, however, and it seems unlikely that there will ever be an entry (other than this one) for 2,5-dimethoxy-4-astatophenethylamine. What might be speculated as to its activity? Probably similar in potency to 2C-I, requiring maybe 10 or 20 milligrams. The duration would be dicey to measure, since the isotope with the longest known half-life is half decayed in about 8 hours, and the longest lived natural isotope (for those who insist on natural rather than man-made things) is half decayed in less than a minute. Two predictions would be pretty solid. You might have quite a job accumulating your 10 milligrams of Astatine, as the most that has so far been made at one time is only about 0.05 micrograms, approximately a millionth of the amount needed. And the second prediction? You would not survive the screaming radiation that would bombard you if you could get the needed 5 or 10 milligrams of radio-astatine onto that magic 4-position, and the resulting 2C-A into your tummy!
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