طرز ساخت ماده مخدراسپایس (ماری جوانای صنعتی ) کانابیس جی دبلیو اچ صفر هیجده JWH-018 Synthesis

طرز ساخت ماده مخدراسپایس (ماری جوانای صنعتی ) کانابیس  JWH-018

این روزها بازار مخدر اسپایس گرم است
کانابیس های صنعتی  دارای اثراتی مشابه با ماری جوانا  ولی بسیاری قویتر هستند
قدرت اثرات کانابیس صنعتی 200 تا 800 برابر قویتر از ماری جوانای طبیعی است
یکی از معروفترین انواع کانابیس های  صنعتی جی دبلیو اچ صفر هیجده است
این کانابیس صنعتی  یکی از رایجترین فرم های کانابیس صناعی است

دکتر جان ویلیام هافمن jwhاولین کاشف کانابینوئید مصنوعی - opium.site

opium.site: مخدر روانگردان کانابیس صنعتی jwh-122 قویتر و سکسی ...

فرمول و متد ساخت کانابیس سنتتیک چیست
فرمول و  طریقه ساخت  کانابیس های صنعتی تا چند سال پیش به عنوان یک راز محسوب می شد
امروز در  فرم تمامی کشورها انواعی از فرمولاسیون برای ساخت انواع کانابیس های صنعتی در دسترس است
 ما برای اگاهی از طریق ساخت  کانابیس های صنعتی (اسپایس ) و موادی که برای ساخت  کانابیس صنعتی لازم است این پست را منتشر کرده ایم  که وقتی چند سال دیگر پای این کانابیس های صنعتی  به ایران باز شد مسئولان بدانند مواد اولیه برای ساخت کانابیس های صنعتی چیست
البته ما به خوبی اگاه هستیم که در ایران هیچکس قادر به ساخت کانابیس صنعتی نیست برای همین این مقاله را منتشر کرده ایم و انهایی هم که بلد هستند  احتیاج به این مقاله ما ندارند
در ضمن این راه تئوریکال  وپیشهادی JWH-018 - Proposed Synthesis است  و فقط برای اگاهی است والا در عمل مشکلات بسیاری است
این لینک هم مربوط به یک ویدیو ساخت ماده مخدر اسپایس یا همان کانابیس صنعتی   است
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opium.site: ساخت مخدر کراک روسی یا دزومورفین از کدئین

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jwh-018 synthesis (unpure) (1-pentyl-3-(1-naphthoyl ... - YouTube
JWH-018 - Proposed SynthesisJWH-018, a synthetic alkyl-amino-indole cannabinoid, has recently been found to be the main psychoactive ingredient in many of the newest generation of "legal highs." Here's the link to the report issued by THC-Pharm, the German firm that was contracted to run the analysis.

http://usualredant.de/drogen/download/analyse-thc-pharm-spic...

Having tried several related products, including one in the report, I can attest that the compound is indeed active and eerily similar to the natural drug it is trying to mimic. Now that I know what I ingested, I've been working on a proposed synthesis.


1 - Oxidation of Indole-3-carbinol to 3-formyl-indole. I'm not particularly farmiliar with indole chemistry, but I'd imagine that being aromatic I'd imagine that it's analogous to benzyl alcohol for this reaction. PCC should work, but I'd rather avoid pyridine. I've found a couple ref's suggesting the ability to stop a Jones reagent from taking it all the way to the carboxylic acid, though;
Quote:

JOC 40(11), 1664-1665, 1975
Selective Oxidation of Allylic Alcohols
with Chromic Acid

Jones Oxidation of Cinnamyl Alcohol. A solution of 500 mg
(3.72 mmol) of cinnamyl alcohol and 10 ml of reagent-grade acetone
was placed in a 50-ml round-bottom flask under nitrogen and
cooled to 0' (ice-water bath). To the magnetically stirred solution
was added dropwise a solution consisting of 2 ml of 8 N Jones reagent
and 18 ml of reagent acetone. The Jones solution was added
over a period of ca. 20 min until an orange tint persisted in the
reaction mixture. Isopropyl alcohol was then added dropwise to
destroy excess Jones reagent, as indicated by the reappearance of a
deep green color. The reaction mixture was then extracted twice
with ether, and the combined ether extracts were washed (water,
sodium bicarbonate, and brine), dried over anhydrous magnesium
sulfate, and concentrated. Evaporative distillation (0.1 mm, 100')
yielded 420 mg (2.96 mmol, 84%) of a cinnamon-smelling, pale yellow
oil (>92% pure by GLC) identified as cinnamaldehyde by comparison
of the ir and NMR spectra with literature spectra.

Jones Oxidation of Benzyl Alcohol. A solutipn of 500 mg (4.63
mmol) of benzyl alcohol and 10 ml of reagent-grade acetone was
placed in a 50-ml round-bottom flask and cooled to 0' (ice-water
bath). Oxidation in the same manner gave material which upon
evaporative distillation (water aspirator pressure, looo) yielded
380 mg (3.52 mmol, 76%) of a clear oil (>99% pure by GLC) identified
by ir and NMR as benzaldehyde.


And, the "Silica Gel Supported Jones Reagent," made by mixing silica gel with the Jones reagent. Supposedly capable of converting benzyl alcohol to benzaldehyde in 85% yield.
http://www.erowid.org/archive/rhodium/chemistry/alcohol2alde...


Step 2 - Grignard reaction between 3-formyl-indole and 1-bromonaphthalene. Again, not too farmiliar with indole chemistry, but the N-proton shouldn't screw with the grignard reagent, would it?

Step 3 - Oxidation of the obtained alcohol to the ketone. Plan is to use Jones reagent.

Step 4 - N-Alkylation to JWH-018. Plan to use same conditions used by J.W. Huffman in original published procedure....I can't seem to find the article at the moment, but IIRC it was n-bromopentane, KOH, and the naphthoyl-indole in DMSO at 80C. I'll replace that with the published procedure when I find it.


This seems simple enough, perhaps even a wal-mart synthesis. Indole-3-carbinol is sold as an anti-cancer supplement for ~$.50-2.00 US / gram by various online health stores, though I've yet to find a local source. Potassium Dichromate has been on my shopping list for some time, and though not necessarily something I can grab at the store, can be had rather cheaply from ebay. The CrO3 required for the Jones reagent can be had from H2SO4 + the dichromate, though I wonder if it would need to be isolated or if the mixture could be used directly?

n-bromopentane would be prepared from n-pentanol and NaBr/H2SO4.

The only thing I haven't worked out yet is the 1-bromonaphthalene... I've found a few articles indicating that it can be made from naphthalene in moderate yeild via Na/KBr and oxone, will post if anyone's interested. Considering I've got a gallon of 27% peroxide and pool season's over (no more oxone locally), anyone have a procedure utilising it?






JWH-018 b.bmp - 267kB
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