لیست ماری جوانا مصنوعی (کانابینوئید صنعتی ) پورفسور(Alexandros Makriyannis ) .

لیست ماری جوانا مصنوعی (کانابینوئید صنعتی ) پورفسورAlexandros Makriyannis   

Alexandros Makriyannis is a professor in the Department of Medicinal Chemistry at Northeastern University, where his research group has synthesized many new compounds with cannabinoid activity. Some of those are:

• AM-087 — an analgesic CB₁ agonist derived from Δ⁸THC substituted with a side chain on the 3-position, it has a K_i of 0.43nM making it roughly 100x as potent as THC.
• AM-251 — an inverse agonist at the CB₁ cannabinoid receptor that is structurally related to SR141716A (rimonabant), but has a higher binding affinity with a K_i value of 7.5nM.^[1]
• AM-281 — N-(morpholin-4-yl)-1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-1H-pyrazole-3-carboxamide^[1]
• AM-356 — a synthetically created stable chiral analog of anandamide, it acts on the cannabinoid receptors with a K_i of 17.9nM at CB₁ and 868nM at CB₂.^[2]
• AM-374 — palmitylsulfonyl fluoride^[3]
• AM-381 — stearylsulfonyl fluoride
• AM-404 — an active metabolite of paracetamol (acetaminophen) and a likely inhibitor of fatty acid amide hydrolase (FAAH)
• AM-411 — an adamantyl-substituted derivative of Δ⁸THC, it is a potent and fairly selective CB₁ full agonist with a K_i of 6.80nM. It is also a moderately potent CB₂ agonist with a K_i of 52.0nM.
• AM-630 — a potent and selective inverse agonist for the cannabinoid receptor CB₂, with a K_i of 32.1nM at CB₂ and 165x selectivity over CB₁, at which it acts as a weak partial agonist.
• AM-661 — 1-(N-methyl-2-piperidine)methyl-2-methyl-3-(2-iodo)benzoylindole^[4]
• AM-678 — another name for JWH-018, it is a full agonist at both cannabinoid receptors with some selectivity for CB₂.
• AM-679 — an iodobenzoylindole which acts as a moderately potent agonist for the cannabinoid receptors, with a K_i of 13.5nM at CB₁ and 49.5nM at CB₂.
• AM-694 — an iodobenzoylindole which acts as a potent and selective agonist for the CB₁ cannabinoid receptor, with a K_i of 0.08nM at CB₁ and 18x selectivity over the related CB₂ receptor (1.44nM).^[5]
• AM-735 — 3-bornyl-Δ8-THC, a mixed CB₁ / CB₂ agonist with K_i of 8.9nM at CB₁ and 7.4nM at CB₂.^[6]
• AM-855 — an analgesic derivative of Δ⁸tetrahydrocannabinol, it is an agonist at both CB₁ and CB₂ with moderate selectivity for CB₁, with a K_i of 22.3nM at CB₁ and 58.6nM at CB₂.
• AM-881 — a chlorine-substituted stereoisomer of anandamide whose K_i = 5.3nM at CB₁ and 95nM at CB₂.^[2]
• AM-883 — an allyl-substituted stereoisomer of anandamide whose K_i = 9.9nM at CB₁ and 226nM at CB₂.^[2]
• AM-905 — a potent and reasonably selective agonist for the CB₁ cannabinoid receptor, with a K_i of 1.2nM at CB₁ and 5.3nM at CB₂.
• AM-906 — a potent and dodecally selective agonist for the CB₁ cannabinoid receptor, with a K_i of 0.8nM at CB₁ and 9.5nM at CB₂.
• AM-919 — a potent agonist at both CB₁ and CB₂ with moderate selectivity for CB₁, with a K_i of 2.2nM at CB₁ and 3.4nM at CB₂. It is a derivative of HU-210 and represents a hybrid structure between the classical and nonclassical cannabinoid families.
• AM-926 — a potent agonist at both CB₁ and CB₂ with moderate selectivity for CB₁, with a K_i of 2.2nM at CB₁ and 4.3nM at CB₂. It is a derivative of HU-210 and represents a hybrid structure between the classical and nonclassical cannabinoid families.
• AM-938 — a potent agonist at both CB₁ and CB₂ with quadruple selectivity for CB₂, with a K_i of 1.2nM at CB₁ and 0.3nM at CB₂. It is a derivative of HU-210 and represents a hybrid structure between the classical and nonclassical cannabinoid families.
• AM-1116 — a dimethylated stereoisomer of anandamide whose K_i = 7.4nM at CB₁.^[2]
• AM-1172 — an endocannabinoid analog specifically designed to be a potent and selective inhibitor of AEA uptake that is resistant to FAAH hydrolysis.
• AM-1220 — a potent and selective analgesic CB₁ agonist (as racemate) with a K_i of 3.88nM at CB₁ and 73.4nM at CB₂, giving it 19x selectivity for CB₁. (R) enantiomer has around 1000x higher affinity for CB₁ than (S) enantiomer.^[7][8]
• AM-1221 — a potent and selective CB₂ agonist with a K_i of 0.28nM at CB₂ and 52.3nM at CB₁, giving it a selectivity of almost 187x.
• AM-1235 — a moderately CB₁ selective agonist, with a K_i of 1.5nM at CB₁ and 20.4nM at CB₂, giving it a selectivity of around 13x.^[9]
• AM-1241 — a potent and selective analgesic CB₂ agonist with a K_i of 3.4nM at CB₂ and 80x selectivity over CB₁.^[10]
• AM-1248 — a moderately potent agonist with some selectivity for CB₁, containing an unusual 3-(adamant-1-oyl) substitution on the indole ring.
• AM-1710 — a CB₂ selective cannabilactone with 54x selectivity over CB₁.^[11]
• AM-1714 — a CB₂ selective cannabilactone with 490x selectivity over CB₁.^[11]
• AM-2201 — a potent agonist at both CB₁ and CB₂ with moderate selectivity for CB₁, with a K_i of 1.0nM at CB₁ and 2.6nM at CB₂.
• AM-2212 — a potent agonist at both CB₁ and CB₂ with dodecal selectivity for CB₁, with a K_i of 1.4nM at CB₁ and 18.9nM at CB₂.^[4]
• AM-2213 — a potent agonist at both CB₁ and CB₂ with 10x selectivity for CB₁, with a K_i of 3.0M at CB₁ and 30nM at CB₂.^[4]
• AM-2232 — a potent agonist at both CB₁ and CB₂, with a K_i of 0.28nM at CB₁ and 1.48nM at CB₂.^[9]
• AM-2233 — (R) enantiomer is potent and selective CB₁ agonist used in ¹³¹I radiolabelled form to map distribution of CB₁ receptors in brain.^{[12][13][14][15][16][17]}
• AM-2389 — classical cannabinoid derivative with 26x selectivity for CB₁.
• AM-3102 — an analog of oleoylethanolamide, the endogenous agonist for proliferator-activated receptor α (PPARα). It also acts as a weak cannabinoid agonist with K_i values of 33µM at CB₁ and 26µM at CB₂.
• AM-4030 — a potent agonist at both CB₁ and CB₂, it is dodecally selective for CB₁, with a K_i of 0.7nM at CB₁ and 8.6nM at CB₂. It is a derivative of HU-210 and represents a hybrid structure between the classical and nonclassical cannabinoid families.
• AM-4054 — a potent but slow-onset agonist with CB₁ affinity of 2.2nM and a 40x selectivity for CB₁ over CB₂.^[18][19]
• AM-4113 — a CB₁ selective neutral antagonist.^[20]
• AM-6545 — a peripherally selective silent antagonist of CB₁ receptors.