Detection of plasma (1 → 3)-β-d-glucan in patients with Fusarium, Trichosporon, Saccharomyces and Acremonium fungaemias
M. Yoshida, T. Obayashi, A. Iwama, M. Ito, S. Tsunoda, T. Suzuki, K. Muroi, M. Ohta, S. Sakamoto & Y. Miura
Abstract
(1 → 3)-β-d-glucan,
a characteristic fungal molecule, is known to increase in blood in
invasive candidiasis, aspergillosis and cryptococcosis. This report
shows that the plasma glucan concentration was also elevated in four
patients infected with Fusarium, Trichosporon beigelii, Saccharomyces cerevisiae and Acremonium.
In three of the patients, the elevation preceded positive blood
cultures by 5–17 days, and in one of them it even preceded the onset of
fever by 6 days. In a fourth patient, the glucan level decreased with
clinical improvement. Plasma (1 → 3)-β-d-glucan determination appears to be useful also for diagnosis and follow-up of these unusual deep mycoses.
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