INTRODUCTIONDue to strangely increased demand for information on 4-methylaminorex chemistry and synthesis that I have received by mail, I decided to compile a short document with the cognate preparation of this interesting compound. This may become a full-fledged FAQ in the future, depending on user response and outside input donated where this will undoubtedly be deficient.DISCLAIMERThis is for informational purposes only. It is being produced in order to illustrate the novel structure and effects of the aryloxazolines. Use this information at your own risk, I cannot be held responsible for what you do with it, etc... and so on.BASIC Q & AQ1. What is 4-methylaminorex?A1. 4-methylaminorex (also called "Ice") is a potent norepinephrine modulator, increasing it's effect. It has a characteristic look and feel, like white opaque ice, hence the name. Ice is currently a Schedule I drug as designated by the DEA (Drug Enforcement Agency) which means it is felt to have NO medical use whatsoever. It was originally researched for appetite suppressant ability, but never pursued, probably because it's too much fun. It is important to know that the slang term 'ice' is also used to refer to methamphetamine. Q2. Can 4-methylaminorex be made from amphetamine/methamphetamine? A2. It is *technically* possible, but requires some backwards motions to get back to a sec. alcohol. At least one individual, in a personal communication to me, indicated that "they knew of someone who could convert crank [methamphetamine] into ice by washing it with something". This is not possible. Q3. What kind of chemical is it? A3. In drug parlance, which is notoriously Non-IUPAC compliant, Ice is synonymous with "Euphoria" (U4Euh), 4-Methylaminorex, or, chemically speaking: dl-cis-2-amino-4-methyl-5-phenyl-2-oxazoline. This is a tongue twister of a name, so I will explain and illustrate it with a cheap floozie of an ascii drawing. . //\ . // \____ _____ ____CH3 . | || | | . | || | | . \\ / O N . \\/ \ // . \// . | . N . / \ . H H The numbering starts at the heterocyclic Oxygen and goes counter-clockwise. So the amine is at the 2 position, the methyl is at the 4 position, a phenyl ring is tacked on at the 5 position. Also, the 2-oxazoline part is often merely called oxazoline, as the double bond to the heterocyclic Nitrogen is implied. It is interesting to note that all of the stereoisomers of 4-MAR are centrally active [1] (ie - it is not stereospecific in action). Q4. What does 4-methylaminorex do? A4. Anecdotally, it is said to help concentration and thinking - a sort of "make-you-smarter" drug, with a minor speed-like component to it. Time of action is around 4-6 hours (some say 14-16). Dosage varies but a good start is 20mg for a 150lb individual. It is smoked as the free base or the hydrochloride salt - both have relatively low melting points. COGNATE PREPARATIONReagents
The ideal ratio of all the reagents is as follows [2]:
The preparation of Cyanogen Bromide is covered in another document of mine. This compound should only be prepared in an area of *adequate* ventillation. A full covering fume hood is ideal (geez - make one, I did) or outside with the wind blowing away from you. Cyanogen Bromide acts on cytochrome oxidase just like any other cyanide and will kill you quite effectively. Also, it has been known to decompose spontaneously when impure.
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ساخت 4 متیل امینو رکس از فنیل پروپانولامین
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