The Clandestine Drug Lab Situation in the United States
This review occurred from 1978-1981 and found three popular methods of meth
manufacture with variations
a mixture of P-2-P, methylamine, mercuric chloride and aluminum metal in alcohol
products of an acetaldehyde/methylamine reaction were refluxed with
benzylmagnesium chloride to form meth
using the Leuckart reaction, P-2-P is refluxed with either methylamine and formic acid
or n-methylformamide to form n-formylmethamphetamine intermediate and then
refluxed the intermediate with hydrochloric acid to form meth
P-2-P mixed with methylamine then reduction of the intermediate 1-phenyl-2-
methyliminopropane to form meth
hydrogenating ephedrine in acetic acid and perchloric acid with palladium on barium
sulfate to form meth
P-2-P and methylamine in the presence of sodium cyanotrihydroborate at a slightly
acidic pH
Resources courtesy of Detective Jeff Seever, Jackson County Drug Task Force
Sodium-Ammonia (“Nazi”) Method
Pseudoephedrine tablets are ground up and stirred in denatured alcohol
Undissolved solids are filtered from tablets using coffee filters
Excess alcohol is evaporated off using hot plates or heat lamps to concentrate
pseudoephedrine
Separately, small pieces of sodium are added to condensed anhydrous ammonia in
thermos jug
With stirring, pseudoephedrine in alcohol is gradually added to the sodium-ammonia
solution over approximately a 10-minute period
The condensed ammonia is allowed to warm to room temperature and evaporate off
Water is added to the remaining solution; ethyl ether (starting fluid) is also added
After stirring, the ether layer is drawn off into a separate container
This review occurred from 1978-1981 and found three popular methods of meth
manufacture with variations
a mixture of P-2-P, methylamine, mercuric chloride and aluminum metal in alcohol
products of an acetaldehyde/methylamine reaction were refluxed with
benzylmagnesium chloride to form meth
using the Leuckart reaction, P-2-P is refluxed with either methylamine and formic acid
or n-methylformamide to form n-formylmethamphetamine intermediate and then
refluxed the intermediate with hydrochloric acid to form meth
P-2-P mixed with methylamine then reduction of the intermediate 1-phenyl-2-
methyliminopropane to form meth
hydrogenating ephedrine in acetic acid and perchloric acid with palladium on barium
sulfate to form meth
P-2-P and methylamine in the presence of sodium cyanotrihydroborate at a slightly
acidic pH
Resources courtesy of Detective Jeff Seever, Jackson County Drug Task Force
Sodium-Ammonia (“Nazi”) Method
Pseudoephedrine tablets are ground up and stirred in denatured alcohol
Undissolved solids are filtered from tablets using coffee filters
Excess alcohol is evaporated off using hot plates or heat lamps to concentrate
pseudoephedrine
Separately, small pieces of sodium are added to condensed anhydrous ammonia in
thermos jug
With stirring, pseudoephedrine in alcohol is gradually added to the sodium-ammonia
solution over approximately a 10-minute period
The condensed ammonia is allowed to warm to room temperature and evaporate off
Water is added to the remaining solution; ethyl ether (starting fluid) is also added
After stirring, the ether layer is drawn off into a separate container
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