β-Glucan exacerbates allergic airway responses to house dust mite allergen

β-Glucan exacerbates allergic airway responses to house dust mite allergen

    Sabelo Hadebe, Frank Kirstein, Kaat Fierens, Pierre Redelinghuys, Graeme I. Murray, David L. Williams, Bart N. Lambrecht, Frank Brombacher and Gordon D. BrownEmail author

Respiratory Research201617:35

DOI: 10.1186/s12931-016-0352-5

©  Hadebe et al. 2016

Received: 22 January 2016

Accepted: 25 March 2016

Published: 2 April 2016
Abstract

β-(1,3)-Glucan is present in mould cell walls and frequently detected in house dust mite (HDM) faeces. β-Glucan exposure is thought to be associated with pulmonary allergic inflammation in mouse and man, although the published data are inconsistent. Here, we show that highly purified β-glucan exacerbates HDM-induced eosinophilic, T helper 2 type airway responses by acting as an adjuvant, promoting activation, proliferation and polarisation of HDM-specific T cells (1-Derβ T cells). We therefore provide definitive evidence that β-glucan can influence allergic pulmonary inflammation.

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