جلوگیری از اثرات مخرب ماری جوانا بر روی حافظه با استفاده از داروی ایبوپروفن و سلکوکسیب Preventing marijuana-induced memory problems with OTC painkillers

جلوگیری از اثرات مخرب ماری جوانا بر روی حافظه با استفاده از داروی ایبوبروفن و سلکوکسیب  

مصرف ماری جوانا در طولانی مدت دارای اثرات مخرب بر روی حافظه است .

تحقیقات جدید ی که در مرکز علوم اعصاب دانشکده بهداشت ایلینویز توسط دکتر چوچن بعمل امده است  نشان می دهد که داروهای  ضد التهاب غیر استروئیدی  مثل ایبوبروفن و سلکوکسیب می تواند از تخریب حافظه موش ها ی که برای درمان الزایمر  به انها ماری جوانا داده اند جلوگیری کند

ماده موثره در ماری جوانا مخدری به نام دلتا 9 تتراهیدروکانابینول است  و زمانی که این ماده وارد مغز می شود باعث ازاد شدن ماده ای به نام انزیم سیکلواکسیژناز در قسمت هیپوکامپ مغز که مسئول حافظه است می شود

ماده سیکلواکسیژناز باعث تخریب مدارات حافظه در هیپوکامپ مغز می شود

داروهای منع کننده انزیم سیکلواکسیژنازCOX-2 inhibitor همانند ایبوبروفن و یا سلکوکسیب با منع ازاد شدن  این انزیم می توانند از اثرات مضر مخدر ماری جوانا بر روی حافظه جلوگیری کنند

Preventing marijuana-induced memory problems with OTC painkillers

New study in Cell suggests that use of medical marijuana could be broadened if patients take NSAIDs like ibuprofen

In addition to being used as a recreational drug, marijuana has been used for centuries to treat a variety of conditions, from chronic pain to epilepsy. However, its medical value is greatly limited by debilitating side effects. A study published by Elsevier's Cell Press today in the journal Cell has revealed the molecular pathways responsible for marijuana-induced learning and memory problems. The findings suggest that preventing these side effects could be as easy as taking an over-the-counter painkiller.
"Our studies have solved the longtime mystery of how marijuana causes neuronal and memory impairments," said senior study author Dr. Chu Chen, Professor of Otorhinolaryngology and Neuroscience at Louisiana State University Health Sciences Center. "The results suggest that the use of medical marijuana could be broadened if patients concurrently take a nonsteroidal anti-inflammatory drug such as ibuprofen."

The main active ingredient in marijuana is Δ 9-tetrahydrocannabinol (Δ9-THC), and drugs based on this compound have been approved by the Food and Drug Administration (FDA) to treat nausea and vomiting in chemotherapy patients. But these drugs have not been approved for a wider range of conditions, in part because of Δ9-THC-induced side effects. Moreover, there are no effective FDA-approved treatments for these side effects because, until now, little was known about the molecular pathways underlying these impairments.

In the new study, Chen and his team discovered that Δ9-THC treatment caused an increase in levels of an enzyme called cyclooxygenase-2 (COX-2) in the mouse hippocampus, a brain region involved in learning and memory. Drugs or genetic techniques that reduced COX-2 levels in mice prevented memory problems and neuronal abnormalities caused by repeated Δ9-THC exposure. Because COX-2 is inhibited by over-the-counter painkillers such as ibuprofen, the findings suggest an easy strategy to prevent the side effects of marijuana.