چهارشنبه ۱۵ خرداد ۱۳۹۲ ه‍.ش.

NMDA receptor antagonist آنتاگونیست های گیرنده ان ام دی ای

NMDA receptor antagonist  آنتاگونیست های گیرنده ان ام دی ای
آنتاگونیست های گیرنده NMDA چیست
اثرات انتاگونیست های NMDA چیست
گیرنده های NMDA  چه کاری انجام می دهد
انتاگونیست های گیرنده NMDA عبارتند از

Adamantanes
  • Amantadine آمانتادین
  • Memantine ممانتین
  • Rimantadine
Arylcyclohexylamines 
  • Dieticyclidine 
  • Esketamine
  • Eticyclidine
  • Gacyclidine
  • Ketamine کتامین
  • Metaphit Metaphit
  • Methoxetamine 
  • Neramexane 
  • Phencyclidine  فن سیکلیدین
  • Phenylhexylcyclopyrrolidine
  • Rolicyclidine
  • Tenocyclidine 
  • Tiletamine 
  • Methoxydine (4-MeO-PCP) )
Morphinans
  • Dextromethorphan دکسترومتورفان
  • Dextrorphan 
  • Methorphan 
  • Morphanol 
  گیرنده های کمتر شناخته شده NMDA
  • 2-MDP 2-MDP
  • 8A-PDHQ 8A-PDHQ
  • Aptiganel Aptiganel
  • Dexoxadrol Dexoxadrol
  • Diethyl ether دی اتیل اتر
  • Dizocilpine
  • Etoxadrol 
  • Ibogaine-  (موجود در iboga Tabernanthe )
  • Midafotel
  • NEFA 
  • Nitrous oxide  اکسید نیتروس
  • Noribogaine
  • Perzinfotel
  • Remacemide
  • Selfotel
  • Xenon گزنون

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لیست برداشت شده از ویکیپدیا:

Competitive antagonists

AP5 (APV, R-2-amino-5-phosphonopentanoate)[27]
AP7 (2-amino-7-phosphonoheptanoic acid)[28]
CPPene (3-[(R)-2-carboxypiperazin-4-yl]-prop-2-enyl-1-phosphonic acid)[29]
Selfotel: an anxiolytic, anticonvulsant but with possible neurotoxic effects.

Uncompetitive channel blockers

Amantadine: used for treating Parkinson's disease and influenza and Alzheimer's.[30][31]
AZD6765
Dextrallorphan: a more potent analogue of dextromethorphan.
Dextromethorphan: a common antitussive found in cough medicines.[32]
Dextrorphan: active metabolite of dextromethorphan.
Diphenidine: a novel designer drug sold on the internet.[33]
Dizocilpine (MK-801): an experimental drug used in scientific research.[34]
Ethanol: also known as alcohol, a widely used legal intoxicant.
Eticyclidine: a Schedule I controlled substance in the United States.
Gacyclidine: an experimental drug developed for neuroprotection.
Ibogaine: a Schedule I controlled substance in the United States.[35][36]
Magnesium
Memantine: treatment for Alzheimer's disease.[37]
Methoxetamine: a novel designer drug sold on the internet.[citation needed]
Nitrous oxide: used for anesthesia, particularly in dentistry.[38]
Phencyclidine: a Schedule I controlled substance in the United States.[35]
Rolicyclidine: a Schedule I controlled substance in the United States.
Tenocyclidine: a Schedule I controlled substance in the United States.
Methoxydine: 4-meo-pcp
Tiletamine: an animal anesthetic.[39]
Xenon: an anesthetic.
Neramexane: a memantine analogue with nootropic, antidepressant properties. Also a nicotinic acetylcholine antagonist.
Eliprodil: an anticonvulsant with neuroprotective drug.
Etoxadrol: a potent dissociative similar to PCP.
Dexoxadrol: similar to etoxadrol.
WMS-2539: potent fluorinated derivative of dexoxadrol.[40]
NEFA: a moderate affinity antagonist.
Remacemide: a low affinity antagonist also a sodium-channel blocker.
Delucemine: also a SSRI with neuroprotective properties.
8A-PDHQ: a high affinity PCP structural analogue.

Non-competitive antagonists

Aptiganel (Cerestat, CNS-1102): binds the Mg2+ binding site within the channel of the NMDA receptor.
HU-211: an enantiomer of the potent cannabinoid HU-210 which lacks cannabinoid effects and instead acts as a potent non-competitive NMDA antagonist.[41]
Remacemide: principle metabolite is an uncompetitive antagonist with a low affinity for the binding site.[42]
Rhynchophylline an alkaloid.
Ketamine: a dissociative psychedelic with depressant properties used as an anesthesia in humans and animals, a possible treatment in bipolar disorder patients with Treatment-resistant depression, and used recreationally for its effects on the CNS[43]

Glycine antagonists

These drugs act at the glycine binding site:

1-Aminocyclopropanecarboxylic acid (ACPC)
7-Chlorokynurenate[44]
DCKA (5,7-dichlorokynurenic acid)[45]
Kynurenic acid: a naturally occurring antagonist[46]
Lacosamide: an investigational drug for the treatment of epilepsy and diabetic neuropathic pain.[47]
L-phenylalanine,[48] a naturally occurring amino acid (equilibrium dissociation constant (KB) from Schild regression is 573 µM[49]).