Fox News: “African plant outlawed in US may offer treatment for addicts”
Sadly Fox only seems to want some information to emerge. This comment by ibogaine treatment advocate Dana Beal was deleted from the Fox News site after 12 hours:
Ibogaine’s receptor “reset” (the reason it can work after a single dose) stems from expression of a nerve growth factor–the peptide GDNF–that actually causes dopamine neurons to re-sprout dendrites and receptors. That’s why ultra-low-dose ibogaine reverses Parkinson’s neuro-degeneration. See https://www.youtube.com/watch?v=XF9f3vspdIQ Like Parkinson’s victims, addicts have lost the ability to “feel” dopamine arousal. For heroin, ibogaine works in 3 stages: 1) within 30 minutes, thru a little understood mechanism, ibogaine suppresses the ADENOLATE CYCLASE spike responsible for withdrawal symptoms. 2) ibogaine, a methoxyl, crosses the blood brain barrier and enzymes turn it into the long-lasting hydroxyl NOR-IBOGAINE, which up-regulates serotonin for weeks to months like a sticky prozac, banishing post-addiction depression. 3) Nor-ibogaine not only keeps generating the nerve growth factor, GDNF itself back-signals to cell nuclei telling them to pump out more GDNF, setting up a benign, self-reinforcing loop that continues dopamine regeneration even as the nor-ibogaine washes out of the body. See http://tinyurl.com/q7j .The initial GDNF spike frequently involves REM-mimesis (the visualizations) as tens of thousands of neurons model adjoining neurons, and the experience of “Ah-hah” moments as they connect. But at the same time, GDNF spikes commandeer a particular MAP kinase pathway that engenders some potassium channel blockade. Which only means ibogaine MUST be given under medical supervision. But that is what makes it work for methamphetamine, cocaine, PTSD, bipolar and a host of other conditions for which we have no good medications.
The Daily Beast article attempts to smear the multi millionaire Gerard Armond Powell who has financially supported the establishment of the RLAC, it seems for no more than being very financially successful. It also mentions the involvement in the clinic of Bwiti shaman Patrick Makala:
The other main figure in RLAC — the Bwiti shaman who leads the ibogaine ceremonies, Patrick Zamba Makala, also known as Moughenda — is under investigation by local authorities, according to Costa Rican press reports. A 10th-generation Bwiti who grew up in Gabon, he was the first person to bring ibogaine to the West. Once a trusted shaman in the ibogaine world, he’s now criticized as irresponsible for an incident that occurred at Iboga House, a clinic he founded in 2009.
The Daily Beast also quotes Dr. Stanley Glick, director of the Center for Neuropharmacology and Neuroscience at Albany Medical College, who is one of the foremost authorities on ibogaine. Glick voiced his concerns about Ibogaine’s hallucinogenic properties:
Overall, Glick said he sees the psychoactive and hallucinogenic aspect of ibogaine to be nothing more than an impediment. “It became clear to me at an early stage that the FDA was never going to approve this drug because of its neurotoxicity,” he said. “I knew we had to try to divorce ourselves from the ibogaine story. It’s baggage that doesn’t do us any good.
Ken Alper of New York University who works with Glick has pointed out these differences in a paper for the Journal for Forensic Sciences:
“Although ibogaine contains an indole ring and is designated as a “hallucinogen,” it is pharmacologically distinct from the “classical” hallucinogens such as LSD, mescaline or psilocybin, which are thought to act by binding as agonists to the serotonin type 2A (5-HT2A) receptor. Serotonin agonist or releasing activity does not appear to explain ibogaine’s effects in opioid withdrawal. There is no anecdotal or preclinical evidence for a significant effect of classical hallucinogens in acute opioid withdrawal, and in the animal model ablation of 90% of the raphe, the major serotonergic nucleus of the brain does not significantly affect the expression of opioid withdrawal. Descriptions of subjective experiences associated with ibogaine differ from those associated with the classical hallucinogens. The visual effects of classical hallucinogens are typically most strongly experienced with eyes open and limited to alterations of colors, textures and patterns. In contrast, the psychoactive state associated with ibogaine is most intensely experienced with the eyes closed and has been described as “oneiric” and likened to a “waking dream,” with interrogatory verbal exchanges involving ancestral and archetypal beings, and movement and navigation within visual landscapes. Another frequently described experience is panoramic memory, the recall of a rapid, dense succession of vivid autobiographical visual memories. Mechanistically, these subjective experiences associated with ibogaine might possibly suggest functional muscarinic cholinergic effects, which are prominent in the mechanisms of dreaming and memory. In animals, ibogaine is reported to enhance spacial memory retrieval, and to produce an atropine-sensitive EEG rhythm, commonly regarded as a model of REM sleep.”(قسمت اول ویتامین D) - (Alkaloids, vitamins, minerals, Protein)